LOCUS CyranoPS 14910 bp DNA linear 12-JUN-2025 DEFINITION Corynebacterium phage CyranoPS. ACCESSION VERSION KEYWORDS . SOURCE Corynebacterium phage CyranoPS ORGANISM Corynebacterium phage CyranoPS Viruses, dsDNA viruses, no RNA stage; Caudovirales; Siphoviridae. REFERENCE 1 (bases 1 to 14910) AUTHORS Rossier,O., Chaouat,E., Hill,O., Bourgeois,R., Fabregues,M., Barkim,A., Batsche,A., Ortheau-Alberti,B., Labarre,C., Lopes,A., Regeard,C., Delesalle,V.A., Garlena,R.A., Russell,D.A., Jacobs-Sera,D. and Hatfull,G.F. TITLE Direct Submission JOURNAL Submitted (12-JUN-2025) Biology, Gettysburg College, 300 N Washington, Gettysburg, PA 17325, USA COMMENT Phage Isolation, DNA preparation and genome annotation performed by the University Paris-Saclay Sequencing by Illumina, 241836x coverage, done at the High-throughput sequencing facility of the Institute for Integrative Biology of the Cell (I2BC). Assembly performed by Newbler and Consed as of Oct 4, 2023 Supported by the Science Education Alliance, Howard Hughes Medical Institute, Chevy Chase, MD. FEATURES Location/Qualifiers source 1..14910 /organism="Corynebacterium phage CyranoPS" /mol_type="genomic DNA" /isolation_source="water in Saint-Forget" /lab_host="Corynebacterium glutamicum MB001" /country="France" /lat_lon="48.70192 N 2.021751 E" /collection_date="01-Oct-2021" /collected_by="Maylis Fabregues and Raphael Bourgeois" /identified_by="Maylis Fabregues and Raphael Bourgeois" /note="complete genome" gene 77..397 /gene="1" /locus_tag="SEA_CYRANOPS_1" CDS 77..397 /gene="1" /locus_tag="SEA_CYRANOPS_1" /codon_start=1 /transl_table=11 /product="terminase, small subnit" /translation="MDQLRLFDPPQPPQRGAGRHEKMVRKALEEAETRGTLTAVDGAA ISLAIANAWALDEAEHEGQPFAVAQITAPFIELMKEIGLIQSEVSTDDDKLALALQEL SATD" gene 351..1808 /gene="2" /locus_tag="SEA_CYRANOPS_2" CDS 351..1808 /gene="2" /locus_tag="SEA_CYRANOPS_2" /codon_start=1 /transl_table=11 /product="terminase, large subunit" /translation="MTSLHLPSKNYLQQTNAPRFITEWPDAPSVGSKVAKVQRSLGSE PLPWQVLAAHAVGARNPDGTPRFPFVLVSVPRQAGKTRASWSWLYHKALTIQKSKNWY TADTGTKARARWLEMVEDSNVSPWAPLTQVKKTNGSEALQFPKLRSQIRPHPPTEDSL HSEQSDMNVIDEGWSYDEAQASALMQAIVPTQATRPHRQTIITSTMGTGESTWFHNLI DRAYAGDPGIFLLDYGIPDSVDPTNLEEVAAHHPAYGLLPGVDLGFFEQSLAQLGTAG FARAMGNRRTATRDSLIPLQVYRAAQTEHVIPPDVFVSFGSAIDLERTETAIAAAAWV DGVPIIEIIDVRPGTTWGVDRLAHLIEKSPAGQTTLVIDRISPSSTLFAEATRANLKP LEISARDLATATVEVWDRMNYRDQNSVLQPRIRFRPDPALDLAVEVADRRNLGDSWTW DRKGSAGSIAALEAATLALHGLLNRPVPAQKPMIY" gene 1864..2898 /gene="3" /locus_tag="SEA_CYRANOPS_3" CDS 1864..2898 /gene="3" /locus_tag="SEA_CYRANOPS_3" /codon_start=1 /transl_table=11 /product="portal protein" /translation="MSLLDRIRKLGQLPQLLATGTAPLSVWAGDHLEQVTSPDYDYLP VTRSQAMAIPAVVRARTLIVTTVARCPIVSDTDEITPGWLHGIAPLGGHPQTEFHRLL NTADDLLFHGSAAWAIERDELGNVTAAVHIPRSLWERTADGTIIVDGVPAPAQEVAVF DGIHGGILTHGARALRDASNILSAAARVADTPAALIELRQTNDAVMTREDIKALIQGY VDARRGKNGGVSYSSSGVEVHEHSLAPENLLIEGRNAAAVDVARLLGVPAPFIDATVG GTSLSYENAASRMTELITFGVAPLLAAISSRLNLSDLTPVGTVSFDTAQIIENISELL PTNNTTNEVA" gene 2898..3614 /gene="4" /locus_tag="SEA_CYRANOPS_4" CDS 2898..3614 /gene="4" /locus_tag="SEA_CYRANOPS_4" /codon_start=1 /transl_table=11 /product="endolysin" /translation="MTRYKVQPGVLTENGWPMVNADKTVSVQVVPAAKKVPLLAGNVA TILNAWIIAFNREVEPIESQVWGWSADNDVWNSNHMSGTAIDIGAPKYPFGKRVMPAA TKAKVRALLDKFNGVVYWGAYWSYPDEMHFQIGLPPSNAKVAELANKLNGGYLNIYGT DTTEPESTSMSLTAAQDQRLNEILENTKTIKNQNNEILKQLGQPGGWPQGGGRTVYDL ISAVAEIEGVPNTRDTLAVI" gene 3689..3799 /gene="5" /locus_tag="SEA_CYRANOPS_5" CDS 3689..3799 /gene="5" /locus_tag="SEA_CYRANOPS_5" /codon_start=1 /transl_table=11 /product="membrane protein" /translation="MALDLLALFVASAIGGTVSAVAVLIAVALWLLKEIT" gene 3800..4078 /gene="6" /locus_tag="SEA_CYRANOPS_6" CDS 3800..4078 /gene="6" /locus_tag="SEA_CYRANOPS_6" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MSNEPTTQQKHPIRAVLRTTAAAIVGFLPILPVIAREFGLVESL PWVASVLAVSAAITRILATEQVENWLNKYAPWLTATETPGKHRKDDNV" gene 4071..5504 /gene="7" /locus_tag="SEA_CYRANOPS_7" CDS 4071..5504 /gene="7" /locus_tag="SEA_CYRANOPS_7" /codon_start=1 /transl_table=11 /product="major capsid and protease fusion protein" /translation="MSKALSILTASQSVTATRYIQPETLTASADEDARELTGLVLPFG KPGRTSRGKLSVTASALQIPEDLKRVKLYRDHSDVGGTPVGYATAAEIKEDGLYMSFR VGATPDGDAALVDVSEGIRDALSVELVSPQISGSQITAAQLSAVAIVAVPAYEDARVQ STPKPAAAKSVMSRLVTRDVITAGNNDTSTLTLREVSNALVARLQGDSTHEDLTAALG EITVSGNPKVTSPTWLGELWNGQPYTRLIVPTMGTATLTDMTLSGWRWVTRPEVDDYA GNLAEIPTNTPTTEPYTVEAKRLAGGHKLDRKYIDFPNAEFIQSYLREMARSYAEKTD ARAATYIVGESTTVLESTSQADLLRAAGKARQIMKRTARVEPTTYLVNSDDLFDLMDI TQLEKPEFLDLLGVDPAAFVDDPAVPAGRVIAYHKEALKFGELPGSPIRVNADDVARG GTDNALFGYYAPYLEDSRGLVAVPFGE" gene 5506..5958 /gene="8" /locus_tag="SEA_CYRANOPS_8" CDS 5506..5958 /gene="8" /locus_tag="SEA_CYRANOPS_8" /codon_start=1 /transl_table=11 /product="head-to-tail adaptor" /translation="MTTVYDATPVTWADMPGEWTNQIARNGEPLSWNMLREGRGMLPV LNPITAAEVREWTGQRLDAANDSKVLHTVIAAVVEMVESWKSTHPDYWPVRWRTATIM LIARYVRRRNSPSGVETVGDMGVAYVSRKDPDIAQMLEISTYTKPVVM" gene 5958..6326 /gene="9" /locus_tag="SEA_CYRANOPS_9" CDS 5958..6326 /gene="9" /locus_tag="SEA_CYRANOPS_9" /codon_start=1 /transl_table=11 /product="tail terminator" /translation="MVLLDIHDWFCSTLNGLGIECTADQRDIQVPGAFITVTKLSDWS IDLTTVVAHGELILMTRDIGGREDLNQKDMLLKAVLEPLRALGVVVTTIRPTEQALPP DSSPLPAIKLEWSLAWEQDQ" gene 6339..6737 /gene="10" /locus_tag="SEA_CYRANOPS_10" CDS 6339..6737 /gene="10" /locus_tag="SEA_CYRANOPS_10" /codon_start=1 /transl_table=11 /product="major tail protein" /translation="MAPKYFRTGSGTLTLGGSSGVDFSAQVTSCTVTPEAGDVITVLS GDTIGNYTANLSVNFLQDLSTAGITAYSFDNAGTTVDFEFVPNTALGAMIAGKVTIDP LPVGGATTEIAQSDVSWTCPELPTFTAATA" gene 6740..7165 /gene="11" /locus_tag="SEA_CYRANOPS_11" CDS 6740..7165 /gene="11" /locus_tag="SEA_CYRANOPS_11" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MSQQTGITVDGARELRRTLKKAGVDVKDDLKASHKSAAQIVMTR GADLCPVAPVSMSSAVPGLLRDSLRAAGTQTAAIVRAGNNRKTAKGVPYAGAIHWGWH KRNIRPNLFLTRAASETEPKWVEEYMNHMNEIIDKVKGV" gene 7167..7448 /gene="12" /locus_tag="SEA_CYRANOPS_12" CDS 7167..7448 /gene="12" /locus_tag="SEA_CYRANOPS_12" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MAIQEVTYLDGKKETATISQGHRIRAEMALSAMGRAVAQNAVTW LNVAAFFAVVNPKKFNFDEFLTWSDTIENIEMVEEQVNPTQADLVLDPQ" gene 7551..9212 /gene="13" /locus_tag="SEA_CYRANOPS_13" CDS 7551..9212 /gene="13" /locus_tag="SEA_CYRANOPS_13" /codon_start=1 /transl_table=11 /product="tape measure protein" /translation="MAGKSAVLSVRIIADATKAAAGFNDAEKQVEGFTGKLDRIGGTV DKAAGYATAAAGAYIGLAKSFTDSASEMEQSTGAVEAVFKGQADQIKQLAAEASKSVG LAASDYQNMASVMGSQLMNMGIAQEEVVGTTSDLITLGGDLASMFGGTTADAVDALSS LLRGERDPIERYAVSMNQAAVNAKMAEMGLSGLEGEAAKQAETQATLALLFEQTADAQ GNFARETDTAAGSAQIAAAEWENAKATLGEQFLPIAVQAAEWLGKIAQAAGENPELFM QIGVAVGVAAGALMGISGTIKVIQSASAAFKIFNMVIAANPVGLAVTAIAALAAGLIY AYQNSETFRNGVDVMGRFVKQQLEWVGETVLAVGQFFTNPIEAVQNFARIAGERLDMV QKILGTVRDWLTRVGDSGTGMGNKIASAIAGVIGWLEKMIGWVRSAWEWVEGLFSSWN KTNNEANNYRGGSITAAGSDPDMTMQLANTEILKFSSTLPDMTMQAAAPDVTAQRVNT LAGISSARGTTIINYEINVSGSLDGDEAAEKIIKLIKKHDDRQAF" gene 9212..10393 /gene="14" /locus_tag="SEA_CYRANOPS_14" CDS 9212..10393 /gene="14" /locus_tag="SEA_CYRANOPS_14" /codon_start=1 /transl_table=11 /product="minor tail protein" /translation="MSTLADSFELQLGINRYITTTSIGTITWTWVRRQAVEGVSIRWG RDSILDSPKQRTATITILEDINFSTREMLDTLPNQMLRLKLNNLSYPVIFEGIIDTIK PFIHGSKQGITVSATESFFTSFSDTRLGTIAEPSEGNPFLRAVSPDYAMTWLTTMRSY VPASTFLRTWPSGASYFAQPEAQKLTVKQIIEAVAAWHPLTYPSWSPDHKQIRSTWAG DFVFGLQPLHQIIDVPSAKVIVSDDVEIDVRTYPKSWTYQQGSAPIGSVSEPEFYRQS WPRGQTNVVSDHLLNFNPNYVTGWINDVIKPGVEALKAQVTSPRKFRFSHNLIGKTDD VFWFPWERNVQQIRITKEPYAELMGIDPVFVPIGGTLKITADDVTHDVNCVWTRKKEE Q" gene 10390..11328 /gene="15" /locus_tag="SEA_CYRANOPS_15" CDS 10390..11328 /gene="15" /locus_tag="SEA_CYRANOPS_15" /codon_start=1 /transl_table=11 /product="minor tail protein" /translation="MKNTDHFNIPYPETTDLVSQFPDQVAKSTAELIDTFLYEQEQKQ TAIDAALAGKAPLSHTHPQSQVTGLDAALAGKAPLSHTHPQSQVTGLDAALAGKAPLS HTHSTSQVTGLDSALQGKAPLSHTHPQSQVTGLDAALAGKAPLSHTHSTSQVTGLDAA LAGKAPLPTLNTRVPENLALRIDTSVGTRVFAGNTMIYGDTGWRDITSIDANASISSG KILLRYLNGVITLRFDSVVTVTKGISLPLGSNWAMATNGYPIERLGSTPDRTVRLSWN GDHQVLTTLDGTVTFIGNINYVARNAYPTSLPGTPA" gene 11343..11537 /gene="16" /locus_tag="SEA_CYRANOPS_16" CDS 11343..11537 /gene="16" /locus_tag="SEA_CYRANOPS_16" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MSIRDLSDEELTTRYVEANEELSRRRRLSEIPTEIRELAQQWRD NGGEDSAIIDAIHTTPTTES" gene complement(11534..12355) /gene="17" /locus_tag="SEA_CYRANOPS_17" CDS complement(11534..12355) /gene="17" /locus_tag="SEA_CYRANOPS_17" /codon_start=1 /transl_table=11 /product="tyrosine integrase" /translation="MLNESVLLSHVRGWRQELIGIGRSKNTVAVRVSYVTRFIKWVNL PLEEITRKHLVGWLAEHPNWEKDTRRSAIASLRGFFTWAHRTGLVNVNAAADLPSAGR KRAVPAPAADYDVMEAIRQSPEWVALAIEVIATCGLRRSEVATLKDSLIQPEGQGWII RVTGKGDVTRIVPCPPHLALRLKKRTGWTFPGGQHGHVSAGWLGKMISRALPPGVTAH KLRHRFASVSYAKTHDLRAIQELLGHASLATTQVYVRVSTTETRAAAEAAWNIAA" gene complement(12362..12709) /gene="18" /locus_tag="SEA_CYRANOPS_18" CDS complement(12362..12709) /gene="18" /locus_tag="SEA_CYRANOPS_18" /codon_start=1 /transl_table=11 /product="immunity repressor" /translation="MTSAFNQAGIIPEWTKQDRIRKARELREMKQSDLATAIGVSRGT LASIEQGVREPRRGEVIAISFATGVSLDWLETGKTPADDNGGGEKWAHWDSNPRPAGI GSKPSDQGGGRVA" gene 12813..13016 /gene="19" /locus_tag="SEA_CYRANOPS_19" CDS 12813..13016 /gene="19" /locus_tag="SEA_CYRANOPS_19" /codon_start=1 /transl_table=11 /product="excise" /translation="MTKFFNMTDKLLTTAEVAERLGISPVTVTWRVRAGHLTPEMKLP GVNGAYLFNPASIDQLTKETQSA" gene 13009..13218 /gene="20" /locus_tag="SEA_CYRANOPS_20" CDS 13009..13218 /gene="20" /locus_tag="SEA_CYRANOPS_20" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MLKEDRDWAIKLTASILEGSINQREIENSKYDLEAIVDEAFEFM KETGTYGLFLFEDHFMEIARKHRRA" gene 13229..13348 /gene="21" /locus_tag="SEA_CYRANOPS_21" CDS 13229..13348 /gene="21" /locus_tag="SEA_CYRANOPS_21" /codon_start=1 /transl_table=11 /product="membrane protein" /translation="MSQWEVFVEIGGVKLLVAIAVTLILLRMVYRMNNEPDHD" gene 13341..13580 /gene="22" /locus_tag="SEA_CYRANOPS_22" CDS 13341..13580 /gene="22" /locus_tag="SEA_CYRANOPS_22" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MTKRIVIEVSRDPQNMNRIQTAIRASLSEFTPREVLAHICYAVM IAAKEVEMTPQEEEAHAALLASAFGFTANAHRSPH" gene 13558..13743 /gene="23" /locus_tag="SEA_CYRANOPS_23" CDS 13558..13743 /gene="23" /locus_tag="SEA_CYRANOPS_23" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MPIDPHTNEFRPSQRDPHGRKCVKCRRIFAADAVPAPDIDGNRI CTDCKHRPALNPPGSLF" gene 13877..14146 /gene="24" /locus_tag="SEA_CYRANOPS_24" CDS 13877..14146 /gene="24" /locus_tag="SEA_CYRANOPS_24" /codon_start=1 /transl_table=11 /product="Hypothetical Protein" /translation="MLDVASQTTSFNIPALLRLIPVVTFLVSSRPNEPYRPIGGMTLT FLTSVGDTRALPPSRRSWPECGAILPLTHNHYQLMIGTIHEHTNP" gene 14127..14576 /gene="25" /locus_tag="SEA_CYRANOPS_25" CDS 14127..14576 /gene="25" /locus_tag="SEA_CYRANOPS_25" /codon_start=1 /transl_table=11 /product="WhiB family transcription factor" /translation="MNTLTLERTQDLTNTCMAPGTDPADWDLPPYYGEPGLVKLDLAI GQAKLVCGGCPLMQACAVQALEQPDTWQDIVIAGVPMFLTLSPGLQLLRITMSDALAM IALGADLDTVHAALKERATTAVAQWYVDHPPKGTRARYRAPVAPVGD" gene 14576..14851 /gene="26" /locus_tag="SEA_CYRANOPS_26" CDS 14576..14851 /gene="26" /locus_tag="SEA_CYRANOPS_26" /codon_start=1 /transl_table=11 /product="HNH endonuclease" /translation="MAGWGGRRAQKLTQLCLATYGDRCHLCGRRGATTADHVVPRSLG GTDELENLRPAHGSCNYSRGNTPLHVWRAKHPIHSSQRPELSPRWGG" ORIGIN 1 cgactttccc ccccacaatt aaggccgcca ccctaccccg tcccctcccc accccctccc 61 ccctaaggat ctcaacatgg atcaattgag actttttgac ccaccacaac caccgcagcg 121 cggtgcaggt cgacatgaaa aaatggttcg taaagcactt gaagaagcgg aaacgcgcgg 181 cactcttacc gcggtcgacg gcgctgcaat ctctctcgca atcgcgaacg cgtgggcact 241 tgatgaagcg gagcacgagg ggcaaccgtt cgccgttgca cagatcaccg ccccgttcat 301 tgaactaatg aaagaaattg gattgattca aagtgaggtg agcacagacg atgacaagct 361 tgcacttgcc ctccaagaac tatctgcaac agactaacgc cccgcgcttt atcacggaat 421 ggccggacgc gcctagtgtt gggtctaagg tagctaaggt tcaacgctcc ctaggttccg 481 aaccactgcc gtggcaggta ctcgcggctc atgcggtagg agcgcgcaac cctgatggaa 541 cgccccgttt cccgtttgtc ttagtctctg ttcctaggca agcgggtaag actcgcgcgt 601 cctggtcgtg gctatatcac aaagcgctga caattcagaa atctaagaat tggtacaccg 661 ccgataccgg cactaaagcg cgcgcccgct ggctggaaat ggtcgaagat tccaacgtgt 721 caccgtgggc accgctaacc caagtcaaaa agaccaacgg tagtgaagcg ctgcagtttc 781 ctaagcttcg ctcacagatc agaccgcacc cacctaccga ggattcatta cattctgaac 841 agtcggacat gaatgtaatt gatgagggct ggtcttacga tgaagcgcaa gctagcgcac 901 tcatgcaagc tatcgttcct actcaggcca cccgcccgca taggcaaacg attatcacta 961 gcacaatggg aacgggtgag tcaacctggt ttcataatct cattgatcgt gcttacgcgg 1021 gcgatcctgg aatctttcta cttgactacg gcatacctga tagtgtagac cccaccaacc 1081 tagaagaagt tgcagcacat cacccggcat atggcctatt gcctggcgtc gacttaggct 1141 tttttgagca atccttagcg cagctaggaa ccgctggttt tgcccgcgct atgggaaacc 1201 gccgtaccgc aacccgtgat tccctaatcc cgctgcaggt gtaccgcgca gcacaaacag 1261 aacatgtcat tccccctgat gtatttgtgt catttggttc tgccatcgac ctagaacgca 1321 cagaaacggc aatcgctgca gctgcttggg tggacggcgt gccaatcatt gaaatcattg 1381 acgttcgccc cggtacaacc tggggcgtcg accgactagc gcacctaatc gaaaaatcac 1441 ccgcaggcca aaccacccta gtgattgacc ggattagtcc aagttctacg ctgttcgcag 1501 aagcaacccg cgcgaacttg aagccactag aaattagtgc ccgtgatctc gccaccgcca 1561 cggttgaagt gtgggacaga atgaactacc gcgatcaaaa ttcagtcctg caaccgcgta 1621 tccgtttcag accagatccc gccctagatc tcgcggtaga agtagccgac cgccgtaacc 1681 ttggcgattc ttggacgtgg gatagaaaag gttccgctgg ttctatcgcc gcgcttgaag 1741 ctgcaaccct tgctttgcat ggcttgctta atcgccccgt acccgcacag aaaccaatga 1801 tctattagcc ccgtgacctg gtaaattctt ccaaaactct tgacagccta aaagatgttg 1861 tttatgagcc tgctagaccg aatcagaaag ctagggcaac tcccgcagct actcgcaaca 1921 ggcaccgccc ctctatctgt atgggcgggc gatcacttag aacaggtcac ctcccctgat 1981 tatgattact tgccggtaac gagatctcag gctatggcaa tccccgcagt agttcgcgcc 2041 cgtactctga ttgtgaccac cgtagctagg tgcccgatag tctccgatac cgacgaaatc 2101 acccccggtt ggctacatgg aatcgccccg ctaggtggac acccacaaac cgagtttcac 2161 cgcttgctaa acaccgccga tgacttgctt tttcatggct ccgcagcgtg ggcaatcgaa 2221 cgagacgaat taggcaacgt caccgcagct gttcacattc cacggtcact ttgggaacgt 2281 accgcagatg gaacaatcat tgtcgacggc gtacccgcgc ccgcgcaaga agttgcggtg 2341 ttcgacggta tccacggcgg aatcttgaca cacggcgcgc gtgctcttcg tgacgcgtcc 2401 aacattcttt ccgctgcagc ccgcgtagca gacacgcccg ccgctcttat cgaactcagg 2461 cagaccaatg acgccgtaat gacccgcgag gacattaaag cgttgatcca aggttatgtc 2521 gacgcccgcc gtgggaagaa tggcggtgtc tcatattcca gtagtggcgt ggaagttcac 2581 gagcactcac tagcccctga aaacttgctt attgagggtc gtaacgctgc agcggtcgac 2641 gtggcaaggc tcttgggcgt acccgcgccg tttattgacg ccacggtagg cggaacctca 2701 cttagctacg aaaacgcagc aagtcgaatg acagaactta ttacctttgg tgttgctccg 2761 ctactcgcgg cgattagtag ccggctaaat ctatcagatt tgacacccgt tggaactgtc 2821 agttttgaca ccgcccagat cattgaaaac atctctgaat tgctccccac taacaacact 2881 actaatgagg ttgcataatg acgcgctata aggtacagcc cggcgttctt accgagaacg 2941 ggtggccgat ggtcaacgca gataagaccg tatccgttca agtagtgccc gctgctaaga 3001 aagttccgtt gcttgccggt aacgtcgcaa ccattcttaa cgcttggatc attgctttca 3061 atagggaagt tgaaccgatt gaatcacaag tgtggggctg gtctgcagac aatgacgtgt 3121 ggaactctaa ccacatgagt ggcaccgcta ttgatattgg cgcaccaaag tatccgttcg 3181 gtaagcgtgt catgcctgca gcgacaaaag caaaagttcg cgccctactt gataagttca 3241 acggcgttgt gtattggggt gcctactggt cttatcccga tgaaatgcac tttcagatcg 3301 gactaccgcc gtcgaacgct aaggttgccg aactcgcgaa caagcttaac ggcggctacc 3361 tcaatatcta cggcaccgac accaccgaac cagaaagcac tagcatgtct cttactgcag 3421 cgcaagacca acgcttgaac gagatcttgg aaaacaccaa gacgattaag aaccaaaaca 3481 acgagatctt gaaacagcta gggcaaccgg gcgggtggcc gcaaggtggc gggcgtaccg 3541 tatacgactt gatttcagcg gttgcggaaa ttgagggcgt acccaacacc cgcgacaccc 3601 tagcggtgat ctaaatgctt acactcattg cgctaggcgc ggtctccgct gctctgatct 3661 caaccactga aaggctcatt aagatctcat ggccttagac ctacttgccc tgttcgttgc 3721 tagtgccata ggtggcacag tttccgccgt agccgtgcta atcgccgttg ctctctggct 3781 actaaaggaa atcacgtaag tgtccaatga acccaccaca cagcagaaac accctatccg 3841 cgcagtactc cgaactaccg cagctgcaat agtcggattc ctcccaattc tcccagtcat 3901 agcccgcgag ttcggcttag tggaatcact tccgtgggta gctagtgtcc ttgccgtatc 3961 cgctgcaatt acacgaatac tcgcaaccga gcaagtcgaa aactggctaa acaaatatgc 4021 cccgtggctc accgctacgg aaacacccgg caaacatcga aaggacgata atgtctaagg 4081 ctctctcaat cctcaccgcg tctcagtctg tcaccgcaac ccgctatatt cagcctgaaa 4141 cactcaccgc aagcgcagac gaggacgccc gcgaactcac tggtttggtg ttgccgttcg 4201 gtaagcctgg tcgcacctca cgcggtaagc tttccgtaac cgctagtgct ctgcagatcc 4261 cagaagatct taagcgcgtg aagctctacc gcgatcactc cgatgttggc ggcactccgg 4321 taggctacgc taccgctgca gaaattaaag aagatggcct atacatgagt ttccgtgtgg 4381 gcgcaacccc tgacggtgac gcggcgttag tcgacgtatc cgagggtatc cgagacgctc 4441 tttccgtgga actggtgtca ccgcagatta gcggatctca gatcaccgca gcgcagcttt 4501 ccgccgtggc aatcgttgcc gtacccgctt acgaggacgc gcgcgtacag tcgaccccta 4561 agcctgcagc cgctaagtct gtcatgtccc gattggtcac ccgtgacgtt attaccgctg 4621 gcaacaacga cacctccacc ttgacacttc gtgaagtctc caatgctttg gtggcgcgcc 4681 tgcagggtga ttccactcat gaagatctca cagcggcact aggtgaaatc accgtatccg 4741 gtaaccctaa ggtcacctcc ccaacgtggc taggtgaact ctggaacggt caaccctaca 4801 cccgcttgat tgtcccaact atgggaactg caaccctaac cgacatgacc ctaagcgggt 4861 ggcggtgggt aacccgcccc gaggtggacg actacgcggg caatcttgcc gagatcccca 4921 ccaacacccc aacgaccgag ccttacaccg tggaagctaa gcgcctggcc ggtggacaca 4981 agcttgatcg taagtacatt gatttcccga atgcggaatt tattcagtcg tacttgcgag 5041 aaatggcgcg cagctatgcc gagaaaaccg acgcccgcgc agcaacctat atcgttggag 5101 aatcaaccac tgttctagag tcgacctcac aggccgactt gctccgcgct gcaggtaagg 5161 cacgccagat tatgaagcgc accgcgcgcg tggaaccaac cacctatttg gtgaactccg 5221 atgatctgtt tgatctcatg gatatcacgc agcttgaaaa gcctgaattt ttggatctct 5281 tgggcgtcga ccccgccgcg tttgtagatg accctgcagt acctgcaggc cgtgtaatcg 5341 cttaccacaa ggaagcgttg aagtttggcg agctccctgg ttcacctatc cgagtcaatg 5401 ccgatgacgt ggcacgcggt ggcactgata acgccctgtt tggctactac gcgccatact 5461 tggaagattc acgcggccta gtcgctgttc cgtttggtga atagcatgac caccgtgtac 5521 gacgcaaccc cagtgacatg ggcggacatg ccgggggagt ggacaaacca aatcgcccga 5581 aatggtgaac cactgtcgtg gaacatgctc cgcgaggggc gcggtatgct ccccgtcctg 5641 aatccgatta cagcggcgga agttagagaa tggacgggac aacgcttgga cgctgctaac 5701 gactccaagg tcttgcatac ggtaatcgct gcagtagtcg aaatggtgga atcgtggaag 5761 tcgacccacc ccgactattg gccggttcga tggcgaacag caacgatcat gctcatagca 5821 cgatacgtta ggcgtcgcaa ctctccgagt ggtgttgaaa cggtgggtga tatgggcgtg 5881 gcctatgtca gtcgaaaaga tcccgacatt gcgcaaatgt tagaaatcag tacctacact 5941 aagccggtcg tgatgtaatg gttctacttg acattcacga ctggttctgt tccaccctga 6001 acggtctagg tatcgagtgc accgcagatc aacgggatat acaagtaccc ggtgctttta 6061 tcacagtgac aaaattaagt gactggtcaa tagacctcac taccgttgtt gcacacggcg 6121 aattgattct tatgacccgc gatattggcg ggcgtgaaga tctcaaccag aaagacatgc 6181 tcttaaaggc cgttcttgaa ccgctccgcg cgttgggcgt ggttgttact acaatccgtc 6241 caacagagca agccctaccc cccgattcct cccccttgcc cgcgatcaaa ttggaatggt 6301 cgcttgcatg ggaacaagac cagtaaggat catttatcat ggctccaaag tatttccgta 6361 ccggctccgg cacactaaca ctaggtggtt cgagcggtgt tgatttctcc gcacaggtga 6421 cctcatgcac tgtcacccca gaagcgggtg atgttattac cgtgctctct ggtgacacta 6481 tcggcaacta caccgcgaac ctatcggtaa acttcctgca ggatctcagc accgctggaa 6541 tcactgctta ctctttcgat aacgcaggta caacggtcga ctttgagttt gtgccaaata 6601 cggcgctagg tgccatgatt gccggtaagg tcaccatcga cccgctaccc gtgggcggtg 6661 ccactaccga gattgcacag tctgacgtgt cctggacgtg ccccgaactg ccaacgttta 6721 ccgcagcaac tgcctagaca tgtcgcaaca aacaggtatc acggttgacg gtgcccgcga 6781 gcttaggcga acgctgaaaa aagcgggcgt tgacgtgaaa gacgatctca aagcaagcca 6841 taaatcggcg gctcaaattg tcatgactcg cggcgctgat ttatgccccg tggcacctgt 6901 cagtatgtct agcgcggtgc ctggcttgct tagagactcg cttagggctg caggcaccca 6961 aaccgctgca atcgttcgcg cgggcaataa tcgtaaaacc gctaagggcg taccttacgc 7021 gggcgcgatt cattggggct ggcataaacg caacattaga cccaatctgt tcttaactcg 7081 cgctgcaagc gagactgaac ctaaatgggt agaagaatac atgaaccata tgaatgaaat 7141 cattgacaaa gtaaagggcg tatgaaatgg ctatccaaga agtaacctac cttgacggca 7201 aaaaagaaac agccactatt tctcaggggc accgtatccg cgcagaaatg gcactttccg 7261 caatgggtag ggcggtagcg caaaacgccg tgacctggct taacgtcgct gctttcttcg 7321 ccgtagtcaa tcctaagaag ttcaattttg acgaatttct cacctggtct gacaccatcg 7381 aaaacattga aatggtggaa gaacaggtaa accctaccca agcggatcta gtgttagatc 7441 cgcaataacc ctagcaatcg ccctccacct ccacccgcga acctttatcg aagatcccct 7501 tgatgatcgc gaattggaga cagtgttaga aatccttgag gagtcccgcc gtggccggta 7561 aaagcgccgt tctatctgtc cgaatcattg cagacgctac taaggctgca gctggattca 7621 acgacgctga aaagcaagta gaaggattta ccggcaagct agacagaatc ggcggcaccg 7681 tcgacaaggc tgcaggctac gcaacagctg cagcgggtgc ctacattggc ttagctaaat 7741 cgttcactga ttccgctagt gaaatggaac aatccacagg cgcggtggaa gctgttttta 7801 aggggcaggc agaccagatt aagcaacttg ctgcagaagc gtctaaatca gtaggtcttg 7861 ctgcaagcga ttaccaaaac atggcgagtg tcatgggttc gcagcttatg aatatgggta 7921 ttgcgcaaga agaggtagta ggcactacat cggatctaat caccttgggc ggtgatctcg 7981 cgtccatgtt tggcggaact acagcggacg ccgtagacgc gctttcctca ctactccggg 8041 gcgagcgcga ccctatcgaa cgctacgcgg tgtccatgaa ccaagcggct gtcaatgcga 8101 aaatggccga aatgggtctt tctggccttg agggtgaagc cgcaaaacag gcagaaacgc 8161 aagcaactct cgcgctgctg tttgaacaaa cagcggacgc acagggaaac tttgcccgcg 8221 agaccgacac cgctgcaggc tccgcacaaa ttgcagctgc agaatgggaa aacgctaaag 8281 cgacactagg tgagcaattc ctaccgattg cggtacaagc tgcagaatgg ctaggtaaaa 8341 tcgcgcaagc tgcaggcgag aaccccgaac tgtttatgca aattggtgta gcggtaggtg 8401 ttgctgcagg cgcgcttatg ggtatctctg gaaccattaa ggttattcag tccgcaagcg 8461 ccgcgtttaa aatctttaat atggtaatcg ctgctaaccc cgttggcctg gccgtgaccg 8521 ctatcgccgc actcgcagcc ggtttgattt acgcttacca aaacagtgag acgttccgta 8581 atggcgtcga cgttatgggt cgctttgtta agcaacaatt ggaatgggta ggcgagactg 8641 ttctagccgt tggacagttt tttactaacc cgattgaagc tgttcagaac ttcgcccgta 8701 ttgcaggcga acgcctggat atggtgcaaa agattctggg aactgttcga gattggctta 8761 cccgtgtggg cgactctgga accggaatgg gaaataagat tgcgtccgct atcgctggtg 8821 tgatcggctg gctagaaaaa atgatcggtt gggtacgcag cgcctgggaa tgggtcgagg 8881 gtctattttc atcgtggaac aagacaaaca acgaagcgaa caactatcgt ggtggttcaa 8941 tcaccgcagc gggtagcgat cccgatatga ctatgcagtt agccaatacc gagatcctga 9001 agttttcttc cacattgccc gatatgacta tgcaggctgc agccccggac gtgaccgcgc 9061 agcgcgtgaa cacactagct ggaatcagtt ccgcacgtgg aacaaccatc attaactatg 9121 agatcaatgt aagcggatct cttgacggtg atgaagcggc ggaaaagatc attaaattga 9181 ttaagaaaca tgacgatagg caggcgtttt aatgagtacg cttgctgatt cttttgagct 9241 gcaattaggt ataaacagat acataacaac aacatctatt gggacaatca catggacgtg 9301 ggttaggcga caggccgttg agggcgtctc tatccggtgg gggcgtgaca gcattttaga 9361 ttcccctaaa cagcgcactg caacgatcac tatcttggaa gatataaatt ttagtacgcg 9421 agaaatgctt gataccctcc ccaaccagat gttgcggctc aaactcaata acttgtcata 9481 tccggttatt tttgagggca ttattgatac aatcaagccg tttattcatg ggtctaaaca 9541 aggtattacg gtatctgcaa ccgagtcatt tttcacttct ttttcagata cccgcctagg 9601 tacgatcgct gaaccatcgg agggtaatcc gttcctacgt gcagtatcac ccgactatgc 9661 aatgacgtgg ctgaccacca tgagaagcta tgtacccgca agtacctttc ttcgcacctg 9721 gcctagtgga gcttcctact ttgcccaacc agaagcacaa aaactaacag tcaaacaaat 9781 tatcgaggcc gttgcagcgt ggcacccgct tacttatccg tcatggtcgc ctgaccataa 9841 acagatacgc agtacatggg ctggtgattt cgtgtttgga ttgcagccac tacaccaaat 9901 tattgatgtg ccatcggcta aagtcatcgt ctctgatgac gtggaaatcg acgtgcgcac 9961 ctacccgaag tcctggacgt accaacaagg atcagcacca atcggcagtg tgtcggaacc 10021 ggaattttac cggcaatcat ggccacgagg tcaaactaac gtagtcagtg accacctgct 10081 caactttaat cccaactacg ttactgggtg gataaatgac gttattaagc cgggtgttga 10141 agccctgaaa gcgcaggtga ctagtcctag gaaattccgt ttctcacata atctgatcgg 10201 caaaactgat gatgtgtttt ggttcccttg ggaacggaac gtgcagcaaa tcaggattac 10261 caaagaacca tatgccgaac ttatgggcat tgatccggtt ttcgttccca ttggcggcac 10321 tctaaaaatc accgctgatg acgtcaccca tgacgttaat tgcgtctgga ctcgtaagaa 10381 agaggagcaa tgaaaaacac tgaccacttc aatattccgt accccgaaac caccgacctg 10441 gtgtcgcaat ttcccgacca agtagctaag tccaccgccg aactgataga cacgttccta 10501 tatgaacagg aacagaaaca aacagcgata gacgcagcgc tagcgggtaa ggctccgttg 10561 tcgcatacgc acccgcagtc tcaggtgacc ggacttgacg cggcacttgc gggtaaggct 10621 ccgctgtcgc atacgcaccc gcagtctcag gtgaccggac ttgacgcagc gctagcgggt 10681 aaggctccgc tgtcgcatac gcatagcact tcgcaggtga ccggcctgga tagcgcgttg 10741 cagggtaagg ctccgctgtc acatacgcac ccgcagtctc aggtgaccgg acttgacgcg 10801 gcacttgcgg gtaaggctcc gctgtcgcat acgcatagca cttcgcaggt gaccggactt 10861 gacgcagcgc tagcgggtaa ggcacccctc cccaccctaa acacccgcgt gccggaaaat 10921 ctagcgctac gtatagatac ttccgtaggc acccgcgtgt ttgcaggcaa cactatgatt 10981 tatggggata ccgggtggcg ggacatcact tccatagacg ccaatgcgtc tatctctagt 11041 gggaaaattt tgcttcgata cctaaatggg gtaatcaccc tccggttcga ttcagttgtg 11101 actgtcacta aggggatcag cctacccctg gggtctaatt gggcaatggc tacaaatggt 11161 tatcctattg agagactagg atctacgcca gatcgaactg ttcggttgtc atggaatggt 11221 gaccaccaag tactaactac gcttgacggt actgtcacat ttattgggaa cataaattat 11281 gtggcacgga acgcgtaccc cacatcacta ccgggcacac ccgcttaaga aaggaataca 11341 tcatgtcaat tcgtgatcta tcagatgaag aactcaccac ccggtacgtg gaagctaacg 11401 aggaattatc gcgccgtcgc cgcttaagcg agatccccac cgagattaga gagcttgccc 11461 aacagtggcg tgataacggt ggtgaagaca gcgcaattat tgacgctatc cacaccaccc 11521 caaccactga aagctaagct gcaatgttcc aagcggcttc ggctgcagcg cgcgtttccg 11581 tagtcgacac gcgaacataa acttgggtag tcgctaatga cgcatggcct aacagctctt 11641 ggatagctct taggtcatgc gtttttgcgt aactcacact cgcgaaacgg tgcctaagct 11701 tatgtgcagt aacacccggt ggaagtgccc gtgaaatcat cttgcccaac cagcccgccg 11761 acacgtgccc atgttgcccc cctggaaaag tccaccccgt gcgcttttta agcctaagcg 11821 ctaggtgagg tgggcaagga acaattcttg taacgtcacc ctttcccgtg accctgataa 11881 tccacccttg cccctccggt tgaataagcg agtctttaag cgttgctacc tcactacgcc 11941 gtagcccaca cgtggcgatt acctcaatgg caagcgctac ccactccggt gattgcctaa 12001 ttgcttccat aacgtcatag tccgcagcgg gcgcgggcac cgcccgttta cgccccgcgc 12061 taggcaagtc cgcagcggcg tttacattca caagaccagt tctgtgcgcc catgtaaaaa 12121 aaccgcgcag gcttgcaata gcgctccgcc gtgtgtcttt ctcccagtta gggtgctctg 12181 caagccaccc aacaaggtgt tttcgtgtga tctcttccaa ggggagattc acccacttga 12241 taaagcgggt tacatatgat acgcgcaccg caaccgtgtt cttggatcgc cctataccaa 12301 tcaattcttg acgccacccc cgaacatgag atagcaaaac agattcattt aacatgatag 12361 attaggctac tctgccgccc ccctggtcgc taggcttaga ccctataccc gcaggtcttg 12421 ggttcgagtc ccaatgggcc cacttttcac ccccgccgtt atcatcggcg ggggtttttc 12481 ctgtttctaa ccaatctaaa gaaacacccg tagcgaacga gattgcgata acttcgccgc 12541 gcctaggctc tctgacaccc tgttcgatac ttgccaaagt tccccggcta acgccgattg 12601 cggttgcaag gtcgctctgt ttcatctccc gcagttcccg cgctttcctt atgcggtctt 12661 gctttgtcca ttctgggata attccggctt gattaaatgc actagtcata tcgctaacgg 12721 tagttaaatt cctgaaattg tgcaatagaa aacatgtcac aacctgccat ttctgacata 12781 tgaaagatat tgactagaca acgggtagtt ttgtgactaa gttctttaat atgacagata 12841 agttgcttac tacagcggaa gttgccgaac gtcttggtat ttcccctgtc actgtcacgt 12901 ggcgtgtgcg agctggtcac ctaaccccgg aaatgaagtt gccgggcgtg aatggtgctt 12961 acctgttcaa tcccgcaagc attgaccagc tgactaagga gactcaaagt gcttaaagag 13021 gatcgtgatt gggcgattaa gctcaccgct tcaattcttg agggttcaat caaccaacgt 13081 gaaattgaaa actccaagta tgacctagaa gcaatcgttg atgaagcgtt tgagttcatg 13141 aaagaaacgg gaacctatgg cctgttcctt tttgaagatc actttatgga gatcgcgagg 13201 aaacaccgcc gtgcatgatc tcaacacaat gtctcaatgg gaagtgttcg tagaaatcgg 13261 cggcgttaag ctcctggtcg ctatcgcagt aactcttatc ctgctccgca tggtctaccg 13321 catgaacaac gaaccagacc atgactaaaa gaatcgttat tgaggtctcg cgagatcccc 13381 aaaacatgaa ccgcattcaa acggcaatcc gcgcgtcact gagtgagttc acacctaggg 13441 aagttcttgc ccatatctgc tacgcggtaa tgatcgcagc caaagaagtg gaaatgaccc 13501 cacaagaaga agaagcgcac gcggcactac ttgcaagcgc gtttggattc actgccaatg 13561 cccatagatc cccacactaa cgagttccga ccctcacagc gcgacccaca cggtcgcaag 13621 tgcgtgaaat gccgtcgaat cttcgcagct gacgccgtac ccgcccccga tattgacggt 13681 aaccggatat gcacagactg caagcacaga ccagcgctta acccccctgg atctctgttc 13741 taaaccccca aaacaatcac gtcgcgcgcc ttgacgtaaa taaggtgaca cgcctagccc 13801 gcgtggttgt ccccggttag agcgggattg cttacccgat gaaagaaaaa gtgcaccggt 13861 caaggaagcc cgggcggtgc tagacgtggc aagtcaaaca acctctttca atatcccggc 13921 attactacga ctaattcccg tagtgacgtt tctagtttct agccgcccta acgaaccata 13981 ccgtccgata ggtggaatga ctttaacgtt ccttacttcg gtaggggaca cccgcgcctt 14041 gcccccctcc cgacgctcct ggccggaatg tggggcgatt ttgccactta ctcataatca 14101 ctaccaatta atgattggaa caattcatga acacactaac ccttgaacgc acgcaagatc 14161 tcactaacac ctgtatggct cctggtactg atccggcgga ctgggacttg cccccgtact 14221 atggcgagcc tggcttagtc aagcttgatc tagcgatagg gcaagccaag ctagtgtgtg 14281 gcgggtgccc gctcatgcag gcgtgtgcag tccaagcact agaacaaccg gacacgtggc 14341 aagatattgt gatcgcgggc gtacctatgt ttctcacgct ctcacctggc ttacagttgc 14401 tccgcatcac gatgtctgac gcgctagcta tgattgcctt aggcgctgat ctagatacag 14461 ttcacgcggc actgaaagaa cgtgcgacca ccgccgtggc gcaatggtat gtagaccacc 14521 ccccaaaggg cacacgcgcc cgctaccgcg ccccggtcgc cccggtgggg gactagtggc 14581 cgggtggggc ggtaggcgcg cccagaagct cacacagcta tgcctagcaa catatggtga 14641 tcgttgtcat ttgtgcggtc gacgcggtgc cacaacagcg gatcatgtcg taccaagatc 14701 tcttggcggc actgatgaac tggagaacct aagacctgct catggttcct gcaactactc 14761 acgcggtaac acgcccttgc atgtatggcg cgcgaaacac cctattcatt cttcacagcg 14821 tcctgaactc tcgccacggt ggggcgggta gccccgccac cgccgtggac tttttaaaaa 14881 atgagtgcct aggaagtccc gcgccagccc //