Hatfull Lab (3)
These are publications from Dr. Graham Hatfull's lab over the years.
This is an excellent review paper for understanding a broad view of what is known about mycobacteriophages, in particular their genomics.
Dr. Graham Hatfull
December 4, 2011
Comparative genomic analysis of 60 Mycobacteriophage genomes: genome clustering, gene acquisition, and gene size.
Journal of molecular biology
Hatfull GF et al, 2010
Hatfull GF et al, 2010
Colloquially known as the "60-phage paper," this paper doubled the previously published number of phages, and introduced several new clusters and pieces of evidence for mosaicism.
Debbie Jacobs-Sera
Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis.
PloS one
Piuri M, Jacobs WR, Hatfull GF, 2009
Piuri M, Jacobs WR, Hatfull GF, 2009
A patient arriving at a clinic in South Africa showing advanced signs of TB infection has a life expectancy of only 15 days. Proper medication can only be prescribed after culturing the clinical sample of M. tuberculosis on different antibiotic media to check resistance, a process that takes nearly 2 weeks.
This paper describes work by Mariana Piuri, a former Hatfull-lab post-doc, who engineered fluorescent phages to assist in rapid, clinical testing of TB antibiotic susceptibility, reducing diagnostic time from 2 weeks to less than 24 hours.
This paper describes work by Mariana Piuri, a former Hatfull-lab post-doc, who engineered fluorescent phages to assist in rapid, clinical testing of TB antibiotic susceptibility, reducing diagnostic time from 2 weeks to less than 24 hours.
Dan Russell
December 15, 2011